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Fig. S4

ID: ZDB-IMAGE-170512-42
Publication: Keightley et al., 2017 - The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger
All Figures: Figures for Keightley et al., 2017

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Figure Caption

Fig. S4

Zbtb11 is dispensable for primitive macrophage development but is required for maintenance of macrophage populations in definitive haemopoiesis (supports Fig. 3h)

a. Macrophages are ablated after 11 h treatment with metronidazole (t=0 hpt);

b. Macrophage repopulation occurs in both control and zbtb11 morphants;

c. Neutrophils in the same animals and conditions as for a are unaffected by macrophage ablation (n=3 experiments; mean ±SEM);

d. Macrophages are depleted in mne at 72-96 hpf (n=3 experiments; each point represents an embryo; pooled data with embryos from individual experiments shown in different colours; 72 hpf, n=32,29; 96 hpf, n=41,38; mean ±SEM; Mann-Whitney test); panels a, b scale bar = 100 μm.

Acknowledgments

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