FIGURE

Fig. S1

ID

ZDB-FIG-170512-39

Publication

Keightley et al., 2017 - The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger

Other Figures

All Figure Page

Back to All Figure Page

Fig. S1

Marsanne is a temperature-sensitive zbtb11 mutant (supports Fig. 1b)

a. Whole-mount in situ hybridization showing staining of mpx+ neutrophils and gross morphology demonstrates severity of the mne myeloid-failure phenotype and the overall dysmorphic phenotype of mne embryos varies with temperature. Grey arrows indicate neutrophils; scale bar = 200 μm;

b. At lower temperature (21°C) neutrophil numbers are partly restored towards normal and at higher temperatures (33°C) the neutrophil deficiency is exacerbated. Left: n=14-16/group; Right: n=12-17/group; mean ±SD, twotailed unpaired t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.