FIGURE

Fig. S1

ID

ZDB-FIG-170512-39

Publication

Keightley et al., 2017 - The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger

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Fig. S1

Marsanne is a temperature-sensitive zbtb11 mutant (supports Fig. 1b)

a. Whole-mount in situ hybridization showing staining of mpx+ neutrophils and gross morphology demonstrates severity of the mne myeloid-failure phenotype and the overall dysmorphic phenotype of mne embryos varies with temperature. Grey arrows indicate neutrophils; scale bar = 200 μm;

b. At lower temperature (21°C) neutrophil numbers are partly restored towards normal and at higher temperatures (33°C) the neutrophil deficiency is exacerbated. Left: n=14-16/group; Right: n=12-17/group; mean ±SD, twotailed unpaired t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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