FIGURE

Fig. S1

ID

ZDB-FIG-170419-8

Publication

Ki et al., 2017 - Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors

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Fig. S1

PDGFRA overexpression causes hyperplasia of OPCs and Schwann cells (a-c) Representative confocal images of the spinal cords of mCherry control (n=3), wild-type PDGFRA (n=3), and mutant PDGFRA (n=3) transgenic 6 dpf larvae in the nf1a^+/+; nf1b^-/-; p53^m/m background. Both (b) wild-type PDGFRA and (c) mutant PDGFRA transgenic larvae demonstrate increased numbers of sox10:mCherry-positive oligodendrocyte progenitor cells (OPCs) as compared to (a) mCherry control larvae in the nf1a^+/+;nf1b^-/- ; p53 ^m/m background. (d) Quantification of the sox10:mCherry-positive OPC number within a 100 μm region of the thoracic spinal cord.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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