FIGURE

Fig. 3

ID

ZDB-FIG-170419-3

Publication

Ki et al., 2017 - Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors

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Fig. 3

PDGFRA-induced zebrafish MPNST tumors exhibit similar histology to that of human MPNSTs. (a–c) The histopathology after H&E staining of the zebrafish MPNSTs was identical in the nf1a^+/−; nf1b^−/−; p53m/m zebrafish when either PDGFRA wild-type or mutant proteins were overexpressed. In each genotype, the zebrafish MPNST histopathology was very similar to that of human MPNSTs. The zebrafish MPNSTs comprise spindle cells that stack into short fascicles, typically with a whirling organization pattern. MPNST cells have long serpentine-like nuclei and are spindle-shaped. (d–i) Markers of cells of neural crest origin were expressed by the zebrafish MPNST tumors, such as S100 (d–f) and Sox10 (g–i). S100 was detected in the cell membrane and nucleus, whereas Sox10 was detected in the nucleus. Scale bar=200 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1; nf1a^p301/+; nf1b^p303/p303; zdf28Tg tp53^zdf1/zdf1; nf1a^p301/+; nf1b^p303/p303; zdf26Tg; zdf28Tg tp53^zdf1/zdf1; nf1a^p301/+; nf1b^p303/p303; zdf27Tg; zdf28Tg
Observed In:	whole organism neurofibrosarcoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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