FIGURE

Fig. 4

ID

ZDB-FIG-170309-17

Publication

Wircer et al., 2017 - Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior

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Fig. 4

Otp paralogs have differential effect on hypothalamic oxt expression.

(A–D) Representative high-resolution micrographs of 5 day-old embryos that were subjected to whole mount in situ hybridization with oxt mRNA probe (dorsal view, anterior to the top). oxt-positive neurons in the posterior tuberculum (PT) of otpa^−/−mutants are marked by a dotted rectangle (B). Scale bar, 20 µm. (E,F) Box and whisker plots showing OXT cell number counts in the neurosecretory preoptic area (NPO; E) and in the PT (F) in various genotypes. The numbers of embryos used for the quantification are indicated above each box. In the NPO, otpa^+/+;otpb^+/+ fish differed significantly only from otpa^−/−;otpb^+/− (*p=0.013) and otpa^−/−;otpb^−/−(***p=0.000). In the PT otpa^+/+;otpb^+/+ differed significantly (***p=0.000) only from otpa^−/−;otpb^+/− and otpa^−/−;otpb^+/+.

Expression Data

Gene:	oxt
Fish:	WT otpa^m866/m866 otpb^sa115/sa115 otpa^m866/m866; otpb^sa115/sa115
Anatomical Terms:	caudal tuberculum preoptic area neurosecretory neuron
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	otpa^m866/m866 otpa^m866/m866; otpb^sa115/sa115
Observed In:	caudal tuberculum preoptic area neurosecretory neuron
Stage:	Day 5

Phenotype Detail

Acknowledgments

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