ZFIN Image: Wircer et al., 2017, Fig. 4

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Figure Caption

Fig. 4

Otp paralogs have differential effect on hypothalamic oxt expression.

(A–D) Representative high-resolution micrographs of 5 day-old embryos that were subjected to whole mount in situ hybridization with oxt mRNA probe (dorsal view, anterior to the top). oxt-positive neurons in the posterior tuberculum (PT) of otpa^−/−mutants are marked by a dotted rectangle (B). Scale bar, 20 µm. (E,F) Box and whisker plots showing OXT cell number counts in the neurosecretory preoptic area (NPO; E) and in the PT (F) in various genotypes. The numbers of embryos used for the quantification are indicated above each box. In the NPO, otpa^+/+;otpb^+/+ fish differed significantly only from otpa^−/−;otpb^+/− (*p=0.013) and otpa^−/−;otpb^−/−(***p=0.000). In the PT otpa^+/+;otpb^+/+ differed significantly (***p=0.000) only from otpa^−/−;otpb^+/− and otpa^−/−;otpb^+/+.

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Acknowledgments

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