FIGURE

Fig. S5

ID

ZDB-FIG-170209-56

Publication

Noack Watt et al., 2016 - The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome

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Fig. S5

Proliferation within pharyngeal arches 1 & 2 is reduced.

(A-C) similar levels of pHH3 staining are present in control, polr1c^-/- and polr1d^-/- embryos at 24 hpf. (D-F) Proliferation at 36 hpf also occurs globally at broadly similar levels in controls and mutant embryos, but there differences in the number of pHH3+ cells within pharyngeal arches 1 and 2. (G-I) Magnified views of pharyngeal arches 1 and 2 (outlined). (J, K) Quantification of pHH3+ labeled cells illustrating no global overall decrease in mutants embryos compared to controls, but a significant decrease in the percentage of pHH3+ cells in pharyngeal arches 1 and 2 in polr1c mutant embryos. polr1d mutant embryos showed a similar level of proliferation as polr1c mutants. Scale bar = 100 μm. * = p < 0.01 and error bars represent 95% confidence intervals.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	polr1c^{hi1124Tg/hi1124Tg} polr1d^{hi2393Tg/hi2393Tg}
Observed In:	pharyngeal arch 1 cell population proliferation pharyngeal arch 2 cell population proliferation
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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