FIGURE

Fig. 2

ID

ZDB-FIG-170209-38

Publication

Noack Watt et al., 2016 - The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome

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Fig. 2

Mutations in polr1c and polr1d disrupt craniofacial development in zebrafish embryos.

24 hpf (A-D), 3 dpf (E-G) and 5 dpf (H-J) polr1c^-/- and polr1d^-/- zebrafish exhibit craniofacial defects, including smaller eyes, a disrupted midbrain-hindbrain boundary and cranial necrosis compared to controls. At 3 dpf, distinct craniofacial anomalies such as a smaller jaw and eyes become apparent. By 5 dpf, polr1c^-/- and polr1d^-/- mutants are distinguished from their control siblings by their smaller head, microphthalmia, jaw hypoplasia, and failure to inflate their swim bladder (E-G). Abbreviations: e, eye; mbhb, midbrain hindbrain boundary; j, jaw; h, heart; sb, swim bladder. Scale bar = 200 μm (A-G) and 500 μm (H-J).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	polr1c^{hi1124Tg/hi1124Tg} polr1d^{hi2393Tg/hi2393Tg}
Observed In:	cranium eye head mandibular arch skeleton midbrain hindbrain boundary swim bladder
Stage Range:	Prim-5 to Day 5

Phenotype Detail

Acknowledgments

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