FIGURE

Fig. 5

ID

ZDB-FIG-170209-41

Publication

Noack Watt et al., 2016 - The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome

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Fig. 5

Pharyngeal arch size is reduced in polr1c^-/- and polr1d^-/- mutants.

(A-C) Immunostaining of 36hpf fli1a:egfp labeled control, polr1c^-/- and polr1d^-/- mutant embryos with Zn-8 (red), which labels the endodermal pouches, revealed comparatively normal pharyngeal arch and pharyngeal pouch patterning. Pharyngeal arches 1–5 are indicated. (D-F) fli1a:egfp labeling of post-migratory NCC illustrates an overall reduction in pharyngeal arch size in polr1c^-/- and polr1d^-/- mutants. Pharyngeal arches 1 and 2 are outlined in red. (G-H) Quantification of pharyngeal arches 1 & 2 (red arrows, D-F) volume revealed a reduction in polr1c^-/- (G) and polr1d^-/- (H) mutants. Scale bar = 100 μm. * = p < 0.05 and error bars represent 95% confidence intervals.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	polr1c^{hi1124Tg/hi1124Tg}; y1Tg polr1d^{hi2393Tg/hi2393Tg}; y1Tg
Observed In:	pharyngeal arch pharyngeal arch 1 pharyngeal arch 2 pharyngeal pouch
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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