FIGURE

Fig. 4

ID

ZDB-FIG-161222-27

Publication

Tappeiner et al., 2016 - Inhibition of the TGF? Pathway Enhances Retinal Regeneration in Adult Zebrafish

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Fig. 4

H&E staining of zebrafish retinas before (uninjured) and after induction of retina degeneration with MNU.

In the non-inhibited (0.1% dimethyl sulfide, DMSO) and inhibited group (small molecule inhibitor SB431542), a reduction of rod cells was observed starting at day 3. In the non-inhibited group the reduction of rod photoreceptors persisted until day 8, whereas in the group with the inhibited TGF? pathway (small molecule inhibitor SB431542) a rapid recovery was observed already at day 5. Scale bar indicates 50 ?m. GC: ganglion cells, INL: inner nuclear layer, ONL: outer nuclear layer, SB: SB431542

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: N-methyl-N-nitrosourea chemical treatment by environment: N-methyl-N-nitrosourea
Observed In:	retina tissue regeneration retinal rod cell
Stage:	Adult

Phenotype Detail

Acknowledgments

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