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Fig. 4
H&E staining of zebrafish retinas before (uninjured) and after induction of retina degeneration with MNU.
In the non-inhibited (0.1% dimethyl sulfide, DMSO) and inhibited group (small molecule inhibitor SB431542), a reduction of rod cells was observed starting at day 3. In the non-inhibited group the reduction of rod photoreceptors persisted until day 8, whereas in the group with the inhibited TGFβ pathway (small molecule inhibitor SB431542) a rapid recovery was observed already at day 5. Scale bar indicates 50 μm. GC: ganglion cells, INL: inner nuclear layer, ONL: outer nuclear layer, SB: SB431542
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