FIGURE

Fig. 4

ID

ZDB-FIG-160823-15

Publication

de Preux Charles et al., 2016 - Preconditioning boosts regenerative programmes in the adult zebrafish heart

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Fig. 4

A single intraperitoneal injection of immunogenic particles triggers the reentry of CMs into the cell cycle. (a-d) Representative heart sections of uninjected transgenic cmlc2:DsRed2-nuc (red) fish controls (a) or injected with Hank′s solution (b), LPS (c) or Zymosan (d) labelled with the cell-cycle marker MCM5 (green). Dashed lines separate compact and trabecular myocardium. Arrows indicate double-positive nuclei. (e,f) Quantification of MCM5-positive CM and non-CM nuclei. (g) Sublocalization of MCM5-positive CMs within the distinct myocardium compartment, the compact (Comp. MC) and trabecular (Trab. MC) myocardium (n ≥ 4 hearts; ≥2 sections per heart; n.s., non-significant; *p < 0.05; ***p < 0.001).

Expression Data

Gene:	DsRed2
Antibody:	Ab1-mcm5
Fish:	f2Tg
Conditions:	chemical treatment by injection: lipopolysaccharide chemical treatment by injection: (1->3)-beta-D-glucan
Anatomical Term:	heart
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	f2Tg
Condition:	chemical treatment by injection: (1->3)-beta-D-glucan
Observed In:	compact layer of ventricle tissue remodeling
Stage:	Adult

Phenotype Detail

Acknowledgments

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