FIGURE

Fig. 1

ID

ZDB-FIG-160823-12

Publication

de Preux Charles et al., 2016 - Preconditioning boosts regenerative programmes in the adult zebrafish heart

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Thoracotomy triggers cell proliferation in the intact zebrafish heart. (a,b) Representative sections of hearts of transgenic fish cmlc2:DsRed2-nuc (red), which demarcate cardiomyocyte (CM) nuclei, labelled with the G1/S-phase marker MCM5 (green). (c,d) Representative sections of hearts after one week of BrdU (green) treatment. Mef2 staining (red) was performed to differentiate CM nuclei from non-CM nuclei. (a′,b′,c′,d′,a′′,b′′,c′′,d′′) Higher magnifications of the framed area shown in the images that are labelled with the same letter without the prime symbol. The same rule applies to all the subsequent figures. Arrows indicate double-positive nuclei. (e-h) Quantification of MCM5- and BrdU-positive CM and non-CM nuclei. (n ≥ 4 hearts; ≥2 sections per heart; ***p < 0.001).

Expression Data

Gene:	DsRed2
Antibodies:	Ab1-mcm5 Ab1-mef2
Fish:	f2Tg
Condition:	surgical manipulation: pericardial cavity
Anatomical Term:	heart
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	f2Tg
Condition:	surgical manipulation: pericardial cavity
Observed In:	cardiac muscle cell re-entry into mitotic cell cycle heart cardiac muscle cell proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Open Biol.