FIGURE
Fig. 6
- ID
- ZDB-FIG-160519-7
- Publication
- Zhang et al., 2016 - A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects
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Fig. 6
Progressive loss of myelination in zebrafish vps11(plt) mutants.Cryosectioned CNS tissue from vps11(plt) mutants and wild-type siblings were immunolabeled with Mbp (myelin; green) and HuCD (neurons; red) at 3 and 5 dpf. (A-A′′) Mbp immunolocalization to Mauthner axons in the hindbrain of wild-type animals at 5 dpf (arrows). (B-B′′) Mbp immunolocalization to Mauthner axons in the hindbrain of vps11(plt) mutants at 5 dpf (arrows). (C-C′′) Mbp immunolocalization in the hindbrain of wild-type animals at 7 dpf. (D-D′′) Significant reduction in Mbp immunolocalization in the hindbrain of vps11(plt) mutants at 7 dpf. |
Expression Data
| Antibody: | |
|---|---|
| Fish: | |
| Anatomical Term: | |
| Stage Range: | Day 5 to Days 7-13 |
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Observed In: | |
| Stage Range: | Day 5 to Days 7-13 |
Phenotype Detail
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