IMAGE

Fig. 6

ID

ZDB-IMAGE-160519-5

Antibodies

Ab1-mbp

Publication

Zhang et al., 2016 - A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects

All Figures

Figures for Zhang et al., 2016

Image

Figure Caption

Fig. 6

Progressive loss of myelination in zebrafish vps11(plt) mutants.Cryosectioned CNS tissue from vps11(plt) mutants and wild-type siblings were immunolabeled with Mbp (myelin; green) and HuCD (neurons; red) at 3 and 5 dpf. (A-A′′) Mbp immunolocalization to Mauthner axons in the hindbrain of wild-type animals at 5 dpf (arrows). (B-B′′) Mbp immunolocalization to Mauthner axons in the hindbrain of vps11(plt) mutants at 5 dpf (arrows). (C-C′′) Mbp immunolocalization in the hindbrain of wild-type animals at 7 dpf. (D-D′′) Significant reduction in Mbp immunolocalization in the hindbrain of vps11(plt) mutants at 7 dpf.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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