FIGURE

Fig. 3

ID

ZDB-FIG-151019-12

Publication

Sztal et al., 2015 - Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function

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Fig. 3

Formation of nemaline bodies and aggregates in Tg(ACTA1^D286G-eGFP)_high zebrafish. a Maximum projection images from time lapse of Tg(ACTA1^D286G-eGFP)_high fish from 56 to 71 hpf showing nemaline bodies distributed throughout the skeletal muscle (arrows). Nemaline bodies’ fragment from 59.5 hpf (arrows), coincident with the formation of aggregates at the myosepta (arrowheads). b Quantification of the mean number of nemaline bodies in Tg(ACTA1^D286G-eGFP) _low (n = 50 per stage) and Tg(ACTA1^D286G-eGFP) (n = 48 per stage) strains. c Quantification of the percentage of fish displaying globular aggregates in Tg(ACTA1^D286G-eGFP) _low and Tg(ACTA1 ^D286G-eGFP) _high strains (n = 50 per stage). Error bars represent SEM from three independent experiments (n = 45 per replicate)

Expression Data

Gene:	EGFP
Fish:	mnu3Tg; mnu5Tg
Anatomical Terms:	myoseptum cellular anatomical structure skeletal muscle cellular anatomical structure
Stage Range:	Long-pec to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mnu3Tg; mnu5Tg mnu4Tg; mnu5Tg
Observed In:	myoseptum cellular anatomical structure skeletal muscle cellular anatomical structure
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Acta Neuropathol.