FIGURE

Fig. 4

ID

ZDB-FIG-150406-29

Publication

Boer et al., 2015 - Fascin1-Dependent Filopodia are Required for Directional Migration of a Subset of Neural Crest Cells

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Fig. 4

fscn1a is required for collective migration of the first NC stream.

Dorsal cranial views of wild type and fscn1a MZ embryos analyzed by RNA in situ hybridization for (A) foxd3 mRNA at 11 hpf, (B) sox10 mRNA at 15 hpf, showing asymmetric dispersion of NC cells in fscn1a MZ (arrow), and (C) dlx2a mRNA at 18, 28 and 36 hpf. Numbers correspond to pharyngeal arches, arrows indicate abnormal NC migration phenotypes observed in dlx2a+ NC cells in fscn1a MZ embryos. Anterior is left in all panels. Phenotypes shown in fscn1a MZ panels were observed in 100% (A) or ~20% (B-C) of embryos examined (n>200).

Expression Data

Genes:	dlx2a foxd3 sox10
Fish:	WT fscn1a^{zd1011/zd1011}
Anatomical Terms:	cranial neural crest neural crest pharyngeal arch 1 pharyngeal arch 2 pharyngeal arch 3 pharyngeal arch 4 pharyngeal arch 5 (all 7)
Stage Range:	1-4 somites to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fscn1a^{zd1011/zd1011}
Observed In:	cranial neural crest cranial neural crest neural crest cell migration neural crest cell differentiation pharyngeal arch 1 cranial neural crest pharyngeal arch 1 neural crest cell migration
Stage Range:	1-4 somites to Prim-25

Phenotype Detail

Acknowledgments

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