FIGURE

Fig. 7

ID

ZDB-FIG-150406-32

Publication

Boer et al., 2015 - Fascin1-Dependent Filopodia are Required for Directional Migration of a Subset of Neural Crest Cells

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Fig. 7

fscn1a is required for development of a subset of NC derivatives.

(A) Lateral views of 3 dpf wt and fscn1a MZ embryos stained for th. sym = sympathetic ganglia, scale bar = 100 µm. Mean area of th+ sympathetic ganglia is plotted in graph on right. (n = 25 wt, 24 fscn1a MZ, ****p<0.0001). (B) Representative images of dbh:gfp+ sympathetic ganglia in 3 dpf wt and fscn1a MZ embryos. Dorsal views, anterior to the left. Scale bar = 25 µm. (C) Representative images of phox2b:gfp+ enteric neurons in 3 dpf wt and fscn1a MZ embryos. Dotted lines outline gut. Scale bar = 100 µm. Number of phox2b:gfp+ enteric neurons in 625 µm region of gut is plotted in graph on right (n = 15 wt, 13 fscn1 MZ, *p = 0.03). (D) ngn1:gfp+ dorsal root ganglia (drg) in 5 dpf wt and fscn1a MZ embryos. Scale bar = 100 µm. (E) Lateral views showing melanophores in 5 dpf wt and fscn1a MZ embryos.

Expression Data

Genes:	EGFP GFP th
Fish:	WT fscn1a^{zd1011/zd1011} sb2Tg w37Tg zdf15Tg fscn1a^{zd1011/zd1011}; sb2Tg fscn1a^{zd1011/zd1011}; w37Tg fscn1a^{zd1011/zd1011}; zdf15Tg
Anatomical Terms:	dorsal root ganglion enteric neuron sympathetic nervous system sympathetic neuron
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fscn1a^{zd1011/zd1011} fscn1a^{zd1011/zd1011}; sb2Tg fscn1a^{zd1011/zd1011}; w37Tg fscn1a^{zd1011/zd1011}; zdf15Tg
Observed In:	dorsal root ganglion enteric neuron melanocyte sympathetic nervous system sympathetic nervous system development
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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