FIGURE

Fig. S8

ID

ZDB-FIG-150316-20

Publication

Maier et al., 2014 - RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities

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Fig. S8

A role for RA in regulating zebrafish otic neurogenesis. Embryos were treated with DMSO, DEAB or RA from 18/20S to 26 hpf. (A–E) The dotted line demarcates the OV. Wild-type embryos treated with DMSO show normal expression of neurog1 (A), while expression is decreased in the OV of wild-type embryos treated with DEAB (B). Otic expression of neurog1 is relatively normal, or slightly reduced, in embryos treated with 5 nM (C), 10 nM RA (D) and 15 nM (E) RA. (F–J) Embryos treated with DMSO show normal expression of neurod1 (F), while expression is decreased in the OV of embryos treated with DEAB (G), and increased in embryos treated with 5 nM (H), 10 nM (I) and 15 nM (J) RA. (K–O) Embryos treated with DMSO show normal otic expression of isl1 (K), while expression is decreased in embryos treated with DEAB (L), and increased in embryos treated with 5 nM (M), 10 nM (N) and 15 nM (O) RA. All panels are lateral views with anterior to the left. Scale bar: 50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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