FIGURE

Fig. 5

ID

ZDB-FIG-150313-26

Publication

De Smet et al., 2014 - Fibroblast Growth Factor Signaling Affects Vascular Outgrowth and Is Required for the Maintenance of Blood Vessel Integrity

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Inhibition of FGFRs during Fin Regeneration in Adult Zebrafish

(A and B) GFP⁺ vessels in the fin of adult Tg(fli1:EGFP)^y1 zebrafish at 7 days after amputation (dpa) of the ventral fin. The amputation line is indicated by a white dotted line. Note the impaired vessel regeneration in the SSR-treated fish (B). The white double arrow denotes the outgrowth length of the new blood vessels in the regenerated fin.

(C and D) Morphometric quantification of the GFP⁺ vessel area (C) or the overall tissue (D) in the regenerating fin of adult Tg(fli1:EGFP)^y1 zebrafish, showing that SSR inhibited vessel regeneration by 40% and tissue regrowth by 33% (data are mean ± SEM. N = 7 per group; p < 0.01 by ANOVA repeated measurements. p < 0.05 versus control at each time point by t test). Scale bars denote 250 μm in (A) and (B).

Expression Data

Gene:	EGFP
Fish:	y1Tg
Conditions:	amputation: caudal fin amputation: caudal fin, chemical treatment: BGJ-398
Anatomical Term:	regenerating fin blood vessel
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg
Condition:	amputation: caudal fin, chemical treatment: BGJ-398
Observed In:	regenerating fin angiogenesis
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Chem. Biol.