FIGURE

Fig. 3

ID

ZDB-FIG-150313-24

Publication

De Smet et al., 2014 - Fibroblast Growth Factor Signaling Affects Vascular Outgrowth and Is Required for the Maintenance of Blood Vessel Integrity

Other Figures

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Fig. 3

Inhibition of FGFRs Results in Reduced VE-Cadherin Junctions

Immunostaining of whole-mount zebrafish embryos for VE-cadherin (A and D, or red in C and F), showing intact and continuous EC-cell contacts in control-treated Tg(fli1:EGFP)^y1 zebrafish embryos at 49 hpf (A–C), while SSR-treated zebrafish (exposure to 75 μM in the swimming water; tissue concentration 2.4 μg SSR/mg protein) (D–F) had a discontinuous VE-cadherin lining with reduced VE-cadherin-positive EC-cell juctions, explaining why ECs became disconnected from each other.

Expression Data

Gene:	EGFP
Antibody:	Ab1-cdh5
Fish:	y1Tg
Condition:	chemical treatment: pharmaceutical
Anatomical Terms:	blood vessel endothelial cell cell-cell junction intersegmental vessel trunk vasculature
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg
Condition:	chemical treatment: pharmaceutical
Observed In:	blood vessel endothelial cell cell-cell junction intersegmental vessel endothelial cell
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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