FIGURE

Fig. 3

ID
ZDB-FIG-150313-24
Publication
De Smet et al., 2014 - Fibroblast Growth Factor Signaling Affects Vascular Outgrowth and Is Required for the Maintenance of Blood Vessel Integrity
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Fig. 3

Inhibition of FGFRs Results in Reduced VE-Cadherin Junctions

Immunostaining of whole-mount zebrafish embryos for VE-cadherin (A and D, or red in C and F), showing intact and continuous EC-cell contacts in control-treated Tg(fli1:EGFP)y1 zebrafish embryos at 49 hpf (A–C), while SSR-treated zebrafish (exposure to 75 μM in the swimming water; tissue concentration 2.4 μg SSR/mg protein) (D–F) had a discontinuous VE-cadherin lining with reduced VE-cadherin-positive EC-cell juctions, explaining why ECs became disconnected from each other.

Expression Data
Gene:
Antibody:
Fish:
Condition:
Anatomical Terms:
Stage: Long-pec

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Condition:
Observed In:
Stage: Long-pec

Phenotype Detail
Acknowledgments
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