ZFIN Image: De Smet et al., 2014, Fig. 5

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Figure Caption

Fig. 5

Inhibition of FGFRs during Fin Regeneration in Adult Zebrafish

(A and B) GFP⁺ vessels in the fin of adult Tg(fli1:EGFP)^y1 zebrafish at 7 days after amputation (dpa) of the ventral fin. The amputation line is indicated by a white dotted line. Note the impaired vessel regeneration in the SSR-treated fish (B). The white double arrow denotes the outgrowth length of the new blood vessels in the regenerated fin.

(C and D) Morphometric quantification of the GFP⁺ vessel area (C) or the overall tissue (D) in the regenerating fin of adult Tg(fli1:EGFP)^y1 zebrafish, showing that SSR inhibited vessel regeneration by 40% and tissue regrowth by 33% (data are mean ± SEM. N = 7 per group; p < 0.01 by ANOVA repeated measurements. p < 0.05 versus control at each time point by t test). Scale bars denote 250 μm in (A) and (B).

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Acknowledgments

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