FIGURE

Fig. 4

ID

ZDB-FIG-150224-16

Publication

Kjaer-Sorensen et al., 2014 - Papp-a2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos

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Fig. 4

Papp-a2 is required for normal development of cranial cartilages. (A) Standard light microscopy images of papp-a2-knockdown and control embryos showing severely reduced jaw development. Lateral views, anterior to the left. (B) staining of papp-a2 knockdown and control embryos showing reduction or absence of the ethmoid (e), trabecula cranii (t), Meckel′s cartilage (m), palatoquadrate (pq), ceratohyal (ch), hyosymplectic (hs), and the five caudal branchial arches (*). Nc, notochord. (C) Flat-mounted 24 hpf zebrafish embryos whole mount in situ stained for dlx2a. Numbers indicate the fraction of embryos displaying the depicted phenotype. Dorsal view, anterior to the left. Arrowheads, clusters of dlx2a-positive postmigratory cranial neural cells.

Expression Data

Gene:	dlx2a
Fish:	WT WT + MO1-pappa2 + MO4-tp53 WT + MO2-pappa2 + MO4-tp53 WT + MO3-pappa2 + MO4-tp53
Knockdown Reagents:	MO1-pappa2 MO2-pappa2 MO3-pappa2 MO4-tp53
Anatomical Term:	cranial neural crest cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-pappa2 + MO4-tp53 WT + MO2-pappa2 + MO4-tp53 WT + MO3-pappa2 + MO4-tp53
Knockdown Reagents:	MO1-pappa2 MO2-pappa2 MO3-pappa2 MO4-tp53
Observed In:	ceratohyal cartilage cranial neural crest cell ethmoid cartilage hyosymplectic cartilage Meckel's cartilage neurocranial trabecula palatoquadrate arch pharyngeal arch 3-7
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.