FIGURE

Fig. 4

ID

ZDB-FIG-141113-4

Publication

McGraw et al., 2014 - Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish

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Fig. 4

Wnt activity is prematurely and progressively decreased in krm1^nl10 mutants. (A-R) Expression of the Wnt targets, lef1, axin2 and sef, in the pLLP at 32, 36 and 40hpf in WT and krm1^nl10 embryos. In WT primordia, expression domains of lef1 (A,C,E), axin2 (G,I,K) and sef (M,O,Q) are progressively decreased between 32 and 40hpf. In krm1^nl10 mutant primordia, Wnt target expression is similar to WT at 32hpf (B,H,N). At 36hpf, expression domains are decreased in mutants compared with WT (D,J,P), and are absent in mutants at 40hpf (F,L,R). dusp6 is expressed in the leading and mid-zones of WT primordia between 32 and 40hpf (S,U,W); expression is absent in the leading zone of krm1^nl10 mutant primordia at these stages (T,V,X). Scale bars: 20 μm.

Expression Data

Genes:	axin2 dusp6 il17rd lef1
Fish:	WT kremen1^nl10/nl10
Anatomical Term:	posterior lateral line primordium
Stage Range:	Prim-15 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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