FIGURE

Fig. S9

ID

ZDB-FIG-141007-51

Publication

Bielczyk-Maczyńska et al., 2014 - A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis

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Fig. S9

MO activities in zebrafish embryos include both sequence-specific RNA binding as well as effects not associated with loss of function of the targeted locus i.e. “off-target” effects. As p53 MO can reduce common off-target effects, the number of thrombocytes was assessed in CHT at 3 dpf in embryos co-injected with p53 MO and gene-specific MOs. Concurrent knock down of p53 with gene-specific MOs did not attenuate the thrombocyte phenotype induced by gene-specific MOs, confirming that the observed decrease in the number of thrombocytes was not induced by off-target effects of MOs. All embryos are oriented with anterior to the left and dorsal to the top.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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