FIGURE

Fig. 3

ID

ZDB-FIG-140902-125

Publication

Zennaro et al., 2014 - Podocyte developmental defects caused by adriamycin in zebrafish embryos and larvae: a novel model of glomerular damage

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Fig. 3

Temporal expression pattern of the podocyte markers nephrin (a) and wt1a/b (b) during early days of development and variation of expression after incubation with adriamycin (ADR) (c) (d).

** P<0.005 vs NT and *** P<0.0001 vs NT. Results are expressed as mean ±SEM of three independent experiments (10 fish per experiment). (e) At 72 hpf light microscopy of a treated fish does not show detectable damage. By transmission electron microscopy, impaired podocyte formation is evident in a treated (f) fish, with few and irregular podocyte processes. At the same time point, the untreated fish (g) shows regular distribution of processes along the glomerular basement membrane. Scale bars = 500 nm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment: Doxorubicin hydrochloride
Observed In:	podocyte pronephric podocyte
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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