FIGURE

Fig. 8

ID

ZDB-FIG-140715-64

Publication

Mackereth et al., 2005 - Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode

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Fig. 8

pax8 acts downstream of foxi1 and in parallel with dlx3b. Wild-type embryos injected with foxi1-MO (A-C), foxi1-MO plus pax8-MO (D-F), dlx3b-MO (G-I), or dlx3b-MO plus pax8-MO (J-L). Images show lateral views of the otic vesicle at 30 hpf (A,D,G,J), or dorsal views of dlx3b expression at 12 hpf (B,E,H,K) and pax2a expression at 12 hpf (C,F,I,L). Anterior is to the left in all specimens. mhb, midbrain-hindbrain border; op, otic placode. Arrowheads mark the otic region of dlx3b expression. Scale bar in L: 50 μm for A,D,G,J; 200 μm for B,C,E,F,H,I,K,L.

Expression Data

Genes:	dlx3b pax2a
Fish:	WT + MO1-foxi1 WT + MO2-dlx3b WT + MO1-foxi1 + MO6-pax8 + MO7-pax8 WT + MO2-dlx3b + MO6-pax8 + MO7-pax8
Knockdown Reagents:	MO1-foxi1 MO2-dlx3b MO6-pax8 MO7-pax8
Anatomical Terms:	midbrain hindbrain boundary neural rod otic placode
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-foxi1 WT + MO1-foxi1 + MO6-pax8 + MO7-pax8 WT + MO2-dlx3b + MO6-pax8 + MO7-pax8
Knockdown Reagents:	MO1-foxi1 MO2-dlx3b MO6-pax8 MO7-pax8
Observed In:	hair cell otic vesicle otic vesicle morphogenesis otolith
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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