FIGURE

Fig. 3

ID

ZDB-FIG-140117-5

Publication

Thi Thu et al., 2013 - tbx2a Is Required for Specification of Endodermal Pouches during Development of the Pharyngeal Arches

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Fig. 3

Knock-down of tbx2a affects pharyngeal arches.

(A, B) tbx2a knock-down results in a loss of GFP-positive pharyngeal arches visualized on a background of ET33-1B transgenics. Alcian Blue-stained cartilages are present in the pharyngeal arches of tp53 morphant (C), but not in the tbx2a/tp53 morphants (D). At 24 hpf, dlx2a-positive streams of migratory NCCs (C) develop normally in the morphant (D) even after injection of a high dose of MO (E). At 48hpf, the patterning of posterior arches is affected (arrows and asterisks in F, G).

Expression Data

Genes:	dlx2a EGFP tbx2a
Fish:	WT WT + MO4-tbx2a sqet331BEt sqet331BEt + MO4-tbx2a
Knockdown Reagent:	MO4-tbx2a
Anatomical Terms:	neural crest pharyngeal arch pharyngeal arch neural crest
Stage Range:	Prim-5 to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO4-tbx2a WT + MO4-tbx2a + MO4-tp53 sqet331BEt + MO4-tbx2a
Knockdown Reagents:	MO4-tbx2a MO4-tp53
Observed In:	pharyngeal arch pharyngeal arch mesenchyme condensation cell pharyngeal arch neural crest cell migration pharyngeal arch 2 pharyngeal arch cartilage pharyngeal pouch pharyngeal system development (all 7)
Stage Range:	Prim-5 to Day 4

Phenotype Detail

Acknowledgments

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