ZFIN ID: ZDB-GENE-990917-4
Gene Name: T-box transcription factor 2a
Gene Symbol: tbx2a    Nomenclature History

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Previous Names: tbx-a, tbxa, zgc:85705

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in animal organ development and pharyngeal system development. Predicted to localize to nucleus. Is expressed in several structures, including digestive system; mesoderm; nervous system; pericardial region; and pronephros. Human ortholog(s) of this gene implicated in vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2).
Genome Resources: Alliance (1),  Gene:573084 (1),  Ensembl(GRCz11):ENSDARG00000018025 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31478 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tbx2 N/A 3
    MO1-tbx2a N/A 3
    MO2-tbx2a N/A 1
    MO3-tbx2a N/A 1
    MO4-tbx2a N/A 2
    MO5-tbx2a N/A 1
    DISEASE ASSOCIATED WITH tbx2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    vertebral anomalies and variable endocrine and T-cell dysfunction Alliance Vertebral anomalies and variable endocrine and T-cell dysfunction 618223
    DISEASE ASSOCIATED WITH tbx2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardiac chamber development (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbx2a-201 (1)    Ensembl 5470
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbx2a No data available
    MARKER RELATIONSHIPS
    tbx2a Contained in: [BAC] CH211-199D18 (1)
    tbx2a Encodes: [EST] IMAGE:7156816 (1)
    [cDNA] MGC:85705 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001102384 (1) 3514 nt
    Genomic RefSeq:NW_018394614 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:B0R122 (1) 686 aa
    Sequence Information (all 19)
    ORTHOLOGY for tbx2a ( Chr: 5 )
    CITATIONS (43)