FIGURE

Fig. 5

ID

ZDB-FIG-131220-39

Publication

Angonin et al., 2013 - Nkd1 functions as a passive antagonist of wnt signaling

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Fig. 5

Figure 5. The silberblick (Wnt11) mutant is sensitive to Nkd1.

The slb mutant undergoes normal convergence and extension (A), which is not affected by knockdown of Nkd1 with morpholinos (B). Overexpression of Nkd1 in slb-/- reduces gsc (D) and chd (F) expression (arrows), relative to controls (C, E) at 50% epiboly (Nkd1 injected: 47% of embryos with reduced chd expression (n=81); 50% of embryos with reduced gsc expression (n=46)). In contrast, knockdown of Nkd1 results in a slight expansion of gsc expression at 30% epiboly (G: ave gsc width=0.35 mm; n=13, H: ave gsc width=0.38 mm; n=22). All embryos are homozygous slb, derived from homozygous slb parents.

Expression Data

Genes:	chrd gsc
Fish:	wnt11f2^tz216/tz216 (AB) wnt11f2^tz216/tz216 + MO2-nkd1 (AB)
Knockdown Reagent:	MO2-nkd1
Anatomical Term:	margin dorsal region
Stage:	50%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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