FIGURE

Fig. 3

ID

ZDB-FIG-131220-36

Publication

Angonin et al., 2013 - Nkd1 functions as a passive antagonist of wnt signaling

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Fig. 3

Figure 3. Nkd1 is insufficient to antagonize constitutively active β-catenin.

Overexpression of ΔN-β-catenin results in a spectrum of dorsal-ventral (D-V) phenotypes ranging from a severe phenotype (A), which shows dramatic reduction in both dorsal and ventral structures to a moderate phenotype (B), which have reduced dorsal and ventral structures. The addition of Nkd1 does not ameliorate the effect of &Delat;N-β-catenin. The distribution of phenotypes in ΔN-β-catenin and nkd1 injections is quantified in (D), with numbers above each column representing n values. Consistent with the 1 dpf phenotype, ΔN-β-catenin overexpression results in expansion of gsc expression (E, F), which is not reduced by the addition of Nkd1 (G) (uninj n=40; ΔN-β-catenin n=32; ΔN-β-catenin+nkd1 n=34).

Expression Data

Gene:	gsc
Fish:	WT
Anatomical Term:	margin dorsal region
Stage:	50%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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