FIGURE

Fig. 1

ID
ZDB-FIG-131017-7
Publication
MacDonald et al., 2013 - The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon
Other Figures
All Figure Page
Back to All Figure Page
Fig. 1

The expression domains of the ascl1a, dlx, and gad1b genes overlap in the forebrain of the embryonic zebrafish. Single z sections on triple fluorescent in situ hybridizations. (A) In the forebrain lateral view of a WT embryo, the dlx1a and ascl1a are co-expressed throughout the telencephalon and prethalamus at 24 hpf, while ascl1b is not co-expressed at this stage. (B) The dlx1a, dlx5a, and gad1b genes are co-expressed in the telencephalon, prethalamus, and hypothalamus at 24 hpf. (C) The dlx1a, dlx5a, and gad1b genes continue to be co-expressed in the telencephalon and prethalamus at 48 hpf. The gad1b expression is increased in the dorsal tip of the telencephalon (arrow). The plane of section for (D) is shown as a dotted line in C′′′. (D) Cross-section showing the co-expression of dlx1a, dlx5a, and gad1b in the prethalamus (arrow). The rostral thalamus (arrowhead) is positive for gad1b expression but not dlx1 or dlx5a. Tel=telencephalon, Pth=prethalamus, Hy=hypothalamus, rTh=rostral thalamus. Scale bar in A–D=100 μm and in E=40 μm.

Expression Data
Genes:
Fish:
Anatomical Terms:
Stage Range: Prim-5 to Long-pec

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 381(1), MacDonald, R.B., Pollack, J.N., Debiais-Thibaud, M., Heude, E., Talbot, J.C., and Ekker, M., The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon, 276-85, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.