Gene

gad1b

ID
ZDB-GENE-030909-3
Name
glutamate decarboxylase 1b
Symbol
gad1b Nomenclature History
Previous Names
  • gad1
  • GAD67 (1)
  • gad67 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable glutamate decarboxylase activity. Acts upstream of or within gamma-aminobutyric acid biosynthetic process and neurotransmitter biosynthetic process. Predicted to be active in cytoplasm and presynaptic active zone. Is expressed in nervous system and neural tube. Used to study epilepsy. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; developmental and epileptic encephalopathy 89; and schizophrenia. Orthologous to human GAD1 (glutamate decarboxylase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
96 figures from 62 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from O'Connor et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gad1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 89 Alliance Developmental and epileptic encephalopathy 89 619124
Associated With gad1b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021115 Pyridoxal-phosphate binding site
Family IPR002129 Pyridoxal phosphate-dependent decarboxylase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Pyridoxal-phosphate binding site Pyridoxal phosphate-dependent decarboxylase Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:Q7ZUS3 587
UniProtKB:A0A2R8QPB1 566
UniProtKB:Q9PWK5 182
UniProtKB:F1Q5U5 613
UniProtKB:O93276 232
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-gad1 polyclonal Rabbit
  • IHC
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations