Gene
gad1b
- ID
- ZDB-GENE-030909-3
- Name
- glutamate decarboxylase 1b
- Symbol
- gad1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable glutamate decarboxylase activity. Acts upstream of or within gamma-aminobutyric acid biosynthetic process. Predicted to be active in cytoplasm and presynaptic active zone. Is expressed in nervous system and neural tube. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; drug psychosis; and heroin dependence. Orthologous to human GAD1 (glutamate decarboxylase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 117 figures from 78 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56253 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ga2303 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| jf49Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa900 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa2304 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13138 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15783 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17561 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20613 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3838Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gad1b | (3) | |
| CRISPR2-gad1b | O'Connor et al., 2018 | |
| CRISPR3-gad1b | Tagore et al., 2023 | |
| MO1-gad1b | N/A | (2) |
| MO2-gad1b | N/A | O'Connor et al., 2018 |
| MO3-gad1b | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 89 | Alliance | Developmental and epileptic encephalopathy 89 | 619124 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| epilepsy | gad1bga2303/ga2303 (WIK) | standard conditions | O'Connor et al., 2018 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021115 | Pyridoxal-phosphate binding site |
| Family | IPR002129 | Pyridoxal phosphate-dependent decarboxylase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Pyridoxal-phosphate binding site | Pyridoxal phosphate-dependent decarboxylase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUS3 | InterPro | 587 | ||||
| UniProtKB:A0A2R8QPB1 | InterPro | 566 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(gad1b:EGFP) |
|
| 1 | (3) | |
| TgBAC(gad1b:GAL4-VP16,myl7:mCherry) |
|
| 3 | (5) | |
| TgBAC(gad1b:GFP) |
|
| 1 | (31) | |
| TgBAC(gad1b-hsp70l:GAL4FF) |
|
| 1 | (2) | |
| TgBAC(gad1b:LOXP-RFP-LOXP-GFP) |
|
| 1 | (32) | |
| Tg(gad1b:mCherry) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-251E16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56253 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194419 (1) | 3233 nt | ||
| Genomic | GenBank:CR384078 (2) | 158424 nt | ||
| Polypeptide | UniProtKB:Q7ZUS3 (1) | 587 aa |
- Duan, W., Huang, G., Sui, Y., Wang, K., Yu, Y., Chu, X., Cao, X., Chen, L., Liu, J., Eichler, E.E., Xiong, B. (2024) Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 121:e2404173121e2404173121
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Kim, T.Y., Roychaudhury, A., Kim, H.T., Choi, T.I., Baek, S.T., Thyme, S.B., Kim, C.H. (2024) Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536. Translational psychiatry. 14:8282
- Naderi, M., Nguyen, T.M.N., Pompili, C., Kwong, R.W.M. (2024) Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions. Frontiers in molecular neuroscience. 17:14832381483238
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Wang, H., Li, X., Li, J., Yu, F., Li, Q., Qin, M., Gui, L., Qian, Y., Huang, M. (2024) Long-term exposure to ionic liquid [C8mim]Br induces the potential risk of anxiety and memory deterioration through disturbing neurotransmitter systems. Neurotoxicology. 104:66-74
- Wang, Y., Sun, X., Xiong, B., Duan, M., Sun, Y. (2024) Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish. International Journal of Molecular Sciences. 25(17):
- Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., Chen, X., Liu, T., Gou, S., Zhang, Y., Liu, X., Ji, Y., Wang, X., Li, Q. (2024) Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports. 25(2):570-592
- Araujo-Silva, H., de Souza, A.M., Mamede, J.P.M., Batistuzzo de Medeiros, S.R., Luchiari, A.C. (2023) Individual differences in response to alcohol and nicotine in zebrafish: gene expression and behavior. Development, growth & differentiation. 65(8):434-445
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
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