Gene

gad1b

ID
ZDB-GENE-030909-3
Name
glutamate decarboxylase 1b
Symbol
gad1b Nomenclature History
Previous Names
  • gad1
  • GAD67 (1)
  • gad67 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in gamma-aminobutyric acid biosynthetic process and neurotransmitter biosynthetic process. Is expressed in nervous system and neural tube. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; schizophrenia; and spastic quadriplegia. Orthologous to human GAD1 (glutamate decarboxylase 1).
Genome Resources
Note
None
Expression
All Expression Data
90 figures from 57 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gad1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spastic quadriplegia Alliance ?Cerebral palsy, spastic quadriplegic, 1 603513
Associated With gad1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021115 Pyridoxal-phosphate binding site
Family IPR002129 Pyridoxal phosphate-dependent decarboxylase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Pyridoxal-phosphate binding site Pyridoxal phosphate-dependent decarboxylase Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:O93276 232
UniProtKB:Q7ZUS3 587
UniProtKB:Q9PWK5 182
UniProtKB:F1Q5U5 613
UniProtKB:A0A2R8QPB1 566
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-gad1 polyclonal Rabbit
  • IHC
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations