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ZIRC
ZFIN ID: ZDB-GENE-030909-3
Gene Name: glutamate decarboxylase 1b
Gene Symbol: gad1b    Nomenclature History

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Previous Names: gad1, GAD67 (1), gad67 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in gamma-aminobutyric acid biosynthetic process. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; schizophrenia; and spastic quadriplegia. Is expressed in central nervous system; eye; neural tube; and neurons. Orthologous to human GAD1 (glutamate decarboxylase 1).
Genome Resources: Alliance (1),  Gene:378441 (1),  Ensembl(GRCz11):ENSDARG00000027419 (2)
GENE EXPRESSION
All Expression Data: 82 figures from 52 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [MGC:56253]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa900 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2304 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13138 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15783 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17561 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20613 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gad1b N/A 2
    MO2-gad1b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gad1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spastic quadriplegia Alliance ?Cerebral palsy, spastic quadriplegic, 1 603513
    DISEASE ASSOCIATED WITH gad1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gamma-aminobutyric acid biosynthetic process (more)
    Molecular Function carboxy-lyase activity (more)
    GO Terms (all 8)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gad1b-202 (1)    Ensembl 3483
    ncRNA gad1b-002 (1) 585
    gad1b-003 (1) 793
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-gad1 polyclonal Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gad1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(gad1b:mCherry) gad1b mCherry Danio rerio 1 1
    TgBAC(gad1b:GAL4-VP16,myl7:mCherry) gad1bmyl7 GAL4mCherryVP16 Danio rerio 3 2
    TgBAC(gad1b:GFP) gad1b GFP Danio rerio 1 12
    TgBAC(gad1b:LOXP-RFP-LOXP-GFP) gad1b GFPRFP Danio rerio 1 14
    MARKER RELATIONSHIPS
    gad1b Contained in: [BAC] DKEY-251E16 (1) (order this)
    gad1b Encodes: [cDNA] MGC:56253 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_194419 (1) 3233 bp
    Genomic GenBank:CR384078 (1) 158424 bp
    Select Tool
    Polypeptide UniProtKB:F1Q5U5 (1) 613 aa
    Sequence Clusters UniGene:81985 (1)
    Sequence Information (all 24)
    ORTHOLOGY for gad1b ( Chr: 6 )
    CITATIONS (128)