FIGURE

Fig. 2

ID

ZDB-FIG-130208-9

Publication

Langworthy et al., 2012 - Schwann cell myelination requires Dynein function

Other Figures

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Fig. 2

Schwann cells are present at peripheral nerves in dync1h1 mutant larvae. (A, B) Images of transverse sections at the level of the mid-trunk of 3 dpf wild-type (A) and dync1h1 mutant (B) larvae labeled with antibodies to reveal Sox10 (red) and acetylated tubulin (green), which mark Schwann cells and axons, respectively. Schwann cells (arrows) are close to axons of motor nerves (mn) and the posterior lateral line nerve (pLLn). Insets are higher magnification views of motor nerves indicated by the dashed boxes. (C, D) Quantification of Schwann cells associated with motor roots (C) and pLLn (D). Significance of differences in Sox10⁺ Schwann cell numbers were calculated using nonparametric Mann–Whitney U analysis. Error bars represent standard error of the mean (SEM). Scale bar equals 80 μm for the main panel and 40 μm for the insets.

Expression Data

Antibodies:	Ab1-sox10 Ab1-tuba
Fish:	WT dync1h1^{hi3684Tg/hi3684Tg}
Anatomical Terms:	motor neuron axon myelinating Schwann cell posterior lateral line nerve axon
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dync1h1^{hi3684Tg/hi3684Tg}
Observed In:	motor neuron axon myelinating Schwann cell posterior lateral line nerve axon
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

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