FIGURE

Fig. 4

ID

ZDB-FIG-130208-11

Publication

Langworthy et al., 2012 - Schwann cell myelination requires Dynein function

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Fig. 4

Loss of dync1h1 function disrupts axon wrapping and Mbp expression by Schwann cells. (A, B) Wild-type and dync1h1 mutant larvae expressing sox10:mRFP (red) and mnx1:GFP (green) and labeled by anti-Mbp antibody (blue). Tube-like Mbp⁺ Schwann cells are evident at some axons of the motor nerve (mn) in wild type (dashed bracket) whereas Mbp^– Schwann cells appear more loosely associated with axons in the mutant (solid bracket). (C, D) Wild-type and dync1h1 mutant larvae expressing sox10:mRFP (red) and labeled by anti-Mbp (green) and anti-acetylated tubulin (AcTub, blue) antibodies. Mbp⁺ Schwann cells ensheath pLLn axons in wild-type. By contrast, RFP⁺ Schwann cells associated with the pLLn in dync1h1^/ mutants do not express Mbp and appear loosely associated with axons. All panels show lateral views of 6 dpf wild-type and dync1h1^/ larvae with anterior to the left and dorsal to the top. Scale bars equal 20 μm (A, B) and 10 μm (C, D).

Expression Data

Genes:	GFP mRFP
Antibody:	Ab1-mbp
Fish:	ml2Tg; vu234Tg dync1h1^{hi3684Tg/hi3684Tg}; ml2Tg; vu234Tg
Anatomical Terms:	motor neuron motor neuron axon myelinating Schwann cell posterior lateral line nerve axon
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dync1h1^{hi3684Tg/hi3684Tg}; ml2Tg; vu234Tg
Observed In:	myelinating Schwann cell
Stage:	Day 6

Phenotype Detail

Acknowledgments

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