FIGURE

Fig. 5

ID

ZDB-FIG-130123-69

Publication

Bhat et al., 2013 - A gene network that coordinates preplacodal competence and neural crest specification in zebrafish

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Fig. 5

Co-misexpressing foxi1 and gata3 in tfap2a/c morphants. A-D, Expression of pax2a in the otic/epibranchial placodes at 12 hpf. E–H, Expression of fgf24 in the otic placode at 12 hpf. I–L, Expression of dlx3b in placodal tissues at 12 hpf. M-P, otic vesicle at 24 hpf. Non-transgenic controls and hs:foxi1-hs:gata3 double transgenic embryos are marked across the top, and the lower half of each panel shows tfap2a/c morphants and double transgenic tfap2a/c morphants. Activation of the transgenes at 7 hpf partially rescued otic development in tfap2a/c morphants. Images show dorsal views with anterior to the top (A-L) or lateral views with anterior to the left (M-P).

Expression Data

Genes:	dlx3b fgf24 pax2a
Fish:	WT x19Tg; x25Tg WT + MO2-tfap2c + MO4-tfap2a x19Tg; x25Tg + MO2-tfap2c + MO4-tfap2a
Condition:	heat shock
Knockdown Reagents:	MO2-tfap2c MO4-tfap2a
Anatomical Terms:	epibranchial field neurogenic field otic placode
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	x19Tg; x25Tg WT + MO2-tfap2c + MO4-tfap2a
Condition:	heat shock
Knockdown Reagents:	MO2-tfap2c MO4-tfap2a
Observed In:	otic placode otic vesicle
Stage Range:	5-9 somites to Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 373(1), Bhat, N., Kwon, H.J., and Riley, B.B., A gene network that coordinates preplacodal competence and neural crest specification in zebrafish, 107-117, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.