FIGURE

Fig. 8

ID

ZDB-FIG-121026-32

Publication

Tanaka et al., 2012 - Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish

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Fig. 8

Dpysl2 and Dpysl3 non-cell autonomously affected the position of Rohon-Beard neurons. (A, B) The distribution of the transplanted wild-type RB neurons in the dpysl2 or dpysl3 morphants at 28 hpf, dorsal view, anterior top. In the dpysl2 morphant, the rhodamine dextran–labeled wild-type RB neurons were observed close to the midline (A, arrows). Similarly, in the dpysl3 morphant, the transplanted wild-type RB neurons were located in the relatively medial region, similar to those observed in the host morphant (B, arrow). (C) The distribution of the transplanted dpysl2 and dpysl3 morphant RB neurons in the wild-type embryos at 28 hpf, dorsal view, anterior top. The transplanted morphant RB neurons were located in the lateral part of the spinal cord, similar to those observed in the host embryos (C, arrow). Broken lines indicate the margin of the spinal cord.

Expression Data

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Antibody Labeling

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Acknowledgments

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Reprinted from Developmental Biology, 370(2), Tanaka, H., Morimura, R., and Ohshima, T., Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish, 223-236, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.