FIGURE

Fig. 8

ID

ZDB-FIG-120720-41

Publication

Huycke et al., 2012 - Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone

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Fig. 8

Cyclopamine (CyA) induces vp edge length reduction. Confocal projections of the Op in larvae treated with CyA. Images are lateral views with dorsal upwards and anterior towards the left. (A-C) Wild-type larvae treated with CyA (B) display a reduction in vp edge length and phenocopy ihha mutants (C). (D) Mutants treated with CyA look similar to untreated siblings. (E) Measurements of vj, jp and vp edge lengths for all four treatment categories. Lengths of vj and jp are not statistically different when compared between all possible combinations of treatments. Length of the vp edge is significantly reduced in CyA-treated wild-type larvae compared with wild-type controls, but is not significantly different from ihha mutants treated with CyA or ethanol. Data are presented as mean±s.d., ^**P<0.01 by Tukey-Kramer test, ne5 per treatment category. vp, edge connecting v and p; vj, edge connecting v and j; jp, edge connecting j and p. Scale bar: 50 μm.

Expression Data

Gene:	EGFP
Fish:	b1212Tg ihha^{hu2131/hu2131}; b1212Tg
Condition:	chemical treatment: Cyclopamine
Anatomical Term:	unspecified
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	b1212Tg ihha^{hu2131/hu2131}; b1212Tg
Condition:	chemical treatment: Cyclopamine
Observed In:	opercle postero-ventral margin
Stage:	Day 6

Phenotype Detail

Acknowledgments

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