FIGURE

Fig. S4

ID

ZDB-FIG-120507-10

Publication

Eauclaire et al., 2012 - Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish

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Fig. S4

Normal biliary anatomy in ren morphants. (A–B) Confocal projections of cytokeratin immunostaining of livers of 5 dpf cont (A) and ren MO (B)-injected larvae, which appear fairly similar. (C) Quantification of duct properties, including total number of ducts, number of interconnecting ducts, number of terminal ductules, duct length, width, and angle. There is a significant difference (**p d 0.005) only in the number of terminal ductules. Note that these differences are considerably more subtle than those in the V-H⁺-ATPase mutants and morphants (Fig. 5 and Table 1).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-ren WT + MO2-ren
Knockdown Reagents:	MO1-ren MO2-ren
Observed In:	intrahepatic bile duct intrahepatic bile duct development
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 365(2), Eauclaire, S.F., Cui, S., Ma, L., Matous, J., Marlow, F.L., Gupta, T., Burgess, H.A., Abrams, E.W., Kapp, L.D., Granato, M., Mullins, M.C., and Matthews, R.P., Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish, 434-444, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.