FIGURE

Fig. 7

ID

ZDB-FIG-111025-25

Publication

Madelaine et al., 2011 - Partially redundant proneural function reveals the importance of timing during zebrafish olfactory neurogenesis

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Fig. 7

In neurog1 mutant zebrafish embryos, residual early-born olfactory neurons fail to express certain EON markers. (A-I) Confocal sections of in situ hybridisation and immunolabelling against robo2 and GFP from the Tg(8.4neurog1:GFP) transgene at 24 hpf in wild type (A-C), neurog1 mutant embryos (D-F) and neurog1 mutant embryos in which Neurod4 has been mis-expressed (G-I). Whereas early-born olfactory neurons in wild-type embryos robustly express robo2, expression is absent in neurog1 mutant embryos; mis-expression of Neurod4 partially rescues robo2 expression. (J-O) Confocal sections of in situ hybridisation and immunolabelling against robo2 and GFP from the Tg(8.4neurog1:GFP) transgene in wild-type (J-L) and neurog1 mutant (M-O) embryos at 36 hpf. The expression of robo2 never recovers in the few early-born olfactory neurons that develop in neurog1 mutant embryos. Scale bars: 10 μm.

Expression Data

Genes:	GFP robo2
Fish:	sb1Tg neurog1^{hi1059Tg/hi1059Tg}; sb1Tg
Anatomical Terms:	olfactory placode pioneer neuron peripheral olfactory organ peripheral olfactory organ sensory neuron
Stage Range:	Prim-5 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	neurog1^{hi1059Tg/hi1059Tg}; sb1Tg
Observed In:	axonogenesis
Stage Range:	Prim-5 to Prim-25

Phenotype Detail

Acknowledgments

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