Gene
robo2
- ID
- ZDB-GENE-001019-1
- Name
- roundabout, axon guidance receptor, homolog 2 (Drosophila)
- Symbol
- robo2 Nomenclature History
- Previous Names
-
- ast
- astray
- sb:eu937
- unp1881
- zmp:0000000549 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable identical protein binding activity. Involved in negative regulation of synapse assembly. Acts upstream of or within several processes, including axon development; regulation of extent of cell growth; and sensory perception of touch. Predicted to be located in cell surface. Predicted to be active in neuron projection. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu937 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
vesicoureteral reflux | Alliance | Vesicoureteral reflux 2 | 610878 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Neural and epithelial cell adhesion domain-containing protein |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9QC44 | InterPro | 1544 | ||||||||||
UniProtKB:A0A8M9QPX8 | InterPro | 1575 | ||||||||||
UniProtKB:A0A8M9QC41 | InterPro | 1591 | ||||||||||
UniProtKB:A0A8M9QHC4 | InterPro | 1586 | ||||||||||
UniProtKB:Q90Z70 | InterPro | 1513 |
1 - 5 of 12 Show all
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance