Gene

robo2

ID
ZDB-GENE-001019-1
Name
roundabout, axon guidance receptor, homolog 2 (Drosophila)
Symbol
robo2 Nomenclature History
Previous Names
  • ast
  • astray
  • sb:eu937
  • unp1881
  • zmp:0000000549 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable identical protein binding activity. Involved in negative regulation of synapse assembly. Acts upstream of or within several processes, including axon development; regulation of extent of cell growth; and sensory perception of touch. Predicted to be located in cell surface. Predicted to be active in neuron projection. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
35 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
30 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With robo2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vesicoureteral reflux Alliance Vesicoureteral reflux 2 610878
1 - 1 of 1
Associated With robo2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin domain subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
1 - 5 of 10 Show all
Domain Details Per Protein
Protein Additional Resources Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin domain subtype Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype 2 Immunoglobulin V-set domain Neural and epithelial cell adhesion domain-containing protein
UniProtKB:A0A8M9QC44 InterPro 1544
UniProtKB:A0A8M9QPX8 InterPro 1575
UniProtKB:A0A8M9QC41 InterPro 1591
UniProtKB:A0A8M9QHC4 InterPro 1586
UniProtKB:Q90Z70 InterPro 1513
1 - 5 of 12 Show all
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ottdart00000001997 (1) Havana 226 nt
ZFIN BLAST
mRNA robo2-201 (1)
Ensembl
Ensembl 4,326 nt
ZFIN BLAST
mRNA robo2-202 (1)
Ensembl
Ensembl 4,161 nt
ZFIN BLAST
mRNA robo2-203 (1)
Ensembl
Ensembl 552 nt
ZFIN BLAST
1 - 4 of 4
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations
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