Gene
robo2
- ID
- ZDB-GENE-001019-1
- Name
- roundabout, axon guidance receptor, homolog 2 (Drosophila)
- Symbol
- robo2 Nomenclature History
- Previous Names
-
- ast
- astray
- sb:eu937
- unp1881
- zmp:0000000549 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Involved in cranial nerve morphogenesis; generation of neurons; and sensory perception of touch. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Orthologous to human ROBO2 (roundabout guidance receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 35 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu937 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
vesicoureteral reflux | Alliance | Vesicoureteral reflux 2 | 610878 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003598 | Immunoglobulin subtype 2 |
Domain | IPR003599 | Immunoglobulin domain subtype |
Domain | IPR003961 | Fibronectin type III |
Domain | IPR007110 | Immunoglobulin-like domain |
Domain | IPR013098 | Immunoglobulin I-set |
Domain | IPR013106 | Immunoglobulin V-set domain |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9QC44
|
1544 | |||||||||
UniProtKB:A0A8M9QPX8
|
1575 | |||||||||
UniProtKB:A0A8M9QC41
|
1591 | |||||||||
UniProtKB:A0A8M9QHC4
|
1586 | |||||||||
UniProtKB:Q90Z70
|
1513 | |||||||||
UniProtKB:A0A8M6YUU1
|
1591 | |||||||||
UniProtKB:A0A8M9QPY1
|
1582 | |||||||||
UniProtKB:A0A8M9Q0I3
|
1595 | |||||||||
UniProtKB:A0A8M9QLH7
|
1540 | |||||||||
UniProtKB:A0A8M9QLH5
|
1571 | |||||||||
UniProtKB:A0A8M9QHC8
|
1533 | |||||||||
UniProtKB:A0A8M9Q0I8
|
1553 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance