Gene

robo2

ID
ZDB-GENE-001019-1
Name
roundabout, axon guidance receptor, homolog 2 (Drosophila)
Symbol
robo2 Nomenclature History
Previous Names
  • ast
  • astray
  • sb:eu937
  • unp1881
  • zmp:0000000549 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Involved in cranial nerve morphogenesis; generation of neurons; and sensory perception of touch. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Orthologous to human ROBO2 (roundabout guidance receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
35 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
30 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With robo2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vesicoureteral reflux Alliance Vesicoureteral reflux 2 610878
Associated With robo2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013106 Immunoglobulin V-set domain
Family IPR032986 Roundabout homologue 1
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Immunoglobulin V-set domain Roundabout homologue 1
UniProtKB:F1QBD4 1387
UniProtKB:B8K0D7 399
UniProtKB:A0A2R8Q4U8 136
UniProtKB:Q804R9 20
UniProtKB:A4JYH1 862
UniProtKB:Q1LY64 128
UniProtKB:Q19S04 111
UniProtKB:Q90Z70 1513
UniProtKB:Q19S05 46
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations