FIGURE

Fig. 7

ID

ZDB-FIG-110909-75

Publication

Rothschild et al., 2011 - CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes cilia

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Fig. 7

Dominant-negative CaMK-II phenocopies camk2g1 morphants. (A-C) Dorsal views of 60 hpf embryos that were uninjected (control) or injected with kidney-targeted wild-type (WT) and dominant negative (DN) GFP-CaMK-II. Cysts are evident in DN CaMK-II embryos as shown in the inset (arrows). (D-F) Control and WT embryos immunostained for α1 Na⁺/K⁺-ATPase undergo proper convolution but DN embryos fail to convolute in proportion to expression (GFP). (D2-F2) Z-stack renderings of the anterior pronephric duct regions outlined by white boxes in D-F. (G-L) Kidney-targeted WT and DN CaMK-II are expressed in pronephric cells, but only DN CaMK-II diminishes P-CaMK-II. Scale bars: 500 μm in A; 20 μm in D,D2 10 μm in G,J.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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