Fig. S3
Dominant-negative inhibition of Bmp/Gdf signaling in the eye. (A and B) Lateral view of DiO-filled retinotectal projections in 5 days post-fertilization (dpf) larvae heatshocked at 12 somites. In controls (A), the entire tectum is innervated. In hs:dnBMPR transgenic animals (B) only dorsal tectum is innervated, similar to radars327. (C and D) Brightfield lateral view of 4 dpf larvae. Control larvae (C) show normal eye size, whereas hs:dnBMPR larvae (D) have smaller eyes similar to radars327. |