FIGURE

Fig. 12

ID

ZDB-FIG-100616-123

Publication

Yao et al., 2010 - Atoh8, a bHLH transcription factor, is required for the development of retina and skeletal muscle in zebrafish

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Fig. 12

Absence of Atoh8 affects the myogenic differentiation of skeletal muscle.

(A–B) transverse section of somites at 3dpf and (C–D) transferse section of somites at 7dpf. (A,C) somites of Atoh8-treated embryos; (B,D) the related controls. Note that the transverse myoseptum of MO-treated embryos is ill-defined and incomplete and that the somites form a U-shape or even appear cuboidal. Somites in controls, on the other hand, are chevron shaped with a distinct somite boundary. In addition, differentiated muscle fibers in myotomes show a less compact and orderly looking arrangement in the morphant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-atoh8 + MO5-tp53
Knockdown Reagents:	MO1-atoh8 MO5-tp53
Observed In:	skeletal muscle cell skeletal muscle cell differentiation somite vertical myoseptum
Stage Range:	Protruding-mouth to Days 7-13

Phenotype Detail

Acknowledgments

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