ZFIN ID: ZDB-FIG-100302-39
Millimaki et al., 2010 - Sox2 is required for maintenance and regeneration, but not initial development, of hair cells in the zebrafish inner ear. Developmental Biology   338(2):262-269 Full text @ Dev. Biol.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Long-pec

Fig. 2 Loss of Sox2 results in macular death. (A–D) AO-labeling of dying cells in a control embryo (A) and sox2 morphants (B–D). Morphants often contained multiple dying cells within sensory epithelia (B), and were observed in apical (C) or basal (D) regions of the maculae (arrowheads). (E and F) Schematic maps depicting the distribution of all AO-positive cells seen in otic vesicles of 33 control embryos (E) or 33 sox2 morphants (F) at 48 hpf. Positions of the utricular macula (u), saccular macula (s) and otoliths are indicated. No AO-positive cells were detected in the lateral wall of the otic vesicle. All images show lateral views with anterior to the left and dorsal to the top.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO2-sox2 standard conditions Long-pec macula saccule cell death increased occurrence, abnormal
Long-pec macula utricle cell death increased occurrence, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 338(2), Millimaki, B.B., Sweet, E.M., and Riley, B.B., Sox2 is required for maintenance and regeneration, but not initial development, of hair cells in the zebrafish inner ear, 262-269, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.