FIGURE

Fig. 8

ID

ZDB-FIG-090720-1

Publication

Blin et al., 2008 - NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain

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Fig. 8

Effect of NR4A2 loss-of-function on motor behaviour and brain catecholamines in larval fish. (A,B,C) Motor activity, measured as distance swam in a 5-minute period, of uninjected, Control MO-, NR4A2-MO1- and NR4A2b-MO2-injected 5-day old (A), 12-day old (B) and 3-month old animals (C). (D) Locomotor activity, measured as distance swam in a 5-minute period, of Control MO-, NR4A2-MO1-, haloperidol-treated or not 12-day old fishes. Values are mean ± SEM. *p < 0.03 and **p < 0.003. (E,F) Monoamine determination by HPLC in head extracts from control, NR4A2-MO1- and NR4A2b-MO2-injected 12-day old larvae. (E) Dopamine level. (F) DOPAC level.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-nr4a2b WT + MO2-nr4a2a,nr4a2b
Knockdown Reagents:	MO2-nr4a2a,nr4a2b MO3-nr4a2b
Observed In:	locomotion involved in locomotory behavior whole organism
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

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Reprinted from Molecular and cellular neurosciences, 39(4), Blin, M., Norton, W., Bally-Cuif, L., and Vernier, P., NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain, 592-604, Copyright (2008) with permission from Elsevier. Full text @ Mol. Cell Neurosci.