FIGURE

Fig. 6

ID

ZDB-FIG-090127-13

Publication

Noël et al., 2008 - Organ-specific requirements for Hdac1 in liver and pancreas formation

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Fig. 6

Loss of hdac1 results in reduced cell proliferation in the organ-forming endoderm. (A–D′) Ventral projections using Tg(gutGFP)^s854 line, stained for PH3-positive cells (red) and Prox1-positive hepatoblasts (blue) at 24 hpf (A, C), and 48 hpf (B, D); dorsal to the top. (E–H) In situ hybridisation analysis of pes expression. Wild type embryos express pes in the organ-forming region at 24 hpf (bracket, E) and hepatic region at 30 hpf (arrowhead, F). hdac1 mutants lack pes expression in the organ-forming endoderm at both 24 and 30 hpf (brackets, G, H). (I, J) hdac1 mutants display a decreased number of PH3-positive cells the endoderm and liver between 24 and 48 hpf. Numbers are supplied in Table 1 and Table 2.

Expression Data

Genes:	GFP pes prox1a
Antibody:	Ab3-prox1
Fish:	WT hdac1^s436/s436 s854Tg hdac1^s436/s436; s854Tg
Anatomical Terms:	endoderm hepatocyte liver liver primordium
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 322(2), Noël, E.S., Casal-Sueiro, A., Busch-Nentwich, E., Verkade, H., Dong, P.D., Stemple, D.L., and Ober, E.A., Organ-specific requirements for Hdac1 in liver and pancreas formation, 237-250, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.