FIGURE

Fig. 4

ID

ZDB-FIG-090114-2

Publication

Parkin et al., 2009 - Hedgehog signalling is required for cloacal development in the zebrafish embryo

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Fig. 4

Expression of putative Hh target genes in Hh mutants. Bmp4 and ptc1 expression in Hh pathway mutants and WT siblings. (A-C) WT siblings, 48, 72 and 120 hpf. bmp4 is diffusely expressed in the proctodeum and posterior gut. By 120 hpf expression is restricted to the anus. (D) ptc1 expression in mesenchyme surrounding the posterior gut in a WT sibling. (E-G) smu, 48, 72, 120 hpf. Although the morphological defects in the smu posterior gut alter the shape of the bmp4 expression domain, there are no changes in the levels expressed. (H) There is no ptc1 expression around the cloacal region with the loss of all Hh signal transduction in the smu mutant. (I-K) syu, 48, 72, 120 hpf. Expression of bmp4 in the syu mutant is little different to the WT siblings. (L) Some ptc1 expression surrounding the posterior gut remains after the loss of shha in syu mutants.

Expression Data

Genes:	bmp4 ptch2
Fish:	Df(Chr07)t4/t4 WT smo^b577/b577
Anatomical Terms:	cloaca gut gut mesenchyme
Stage Range:	Long-pec to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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