Gene

ptch2

ID

ZDB-GENE-980526-44

Name

patched 2

Symbol

ptch2 Nomenclature History

Previous Names

ptc-1
ptc1
blowout (1)
blw (1)
etID309849.2 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in several processes, including cardioblast differentiation; negative regulation of smoothened signaling pathway; and retinal ganglion cell axon guidance. Predicted to localize to plasma membrane. Used to study coloboma. Human ortholog(s) of this gene implicated in basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Is expressed in several structures, including central nervous system; digestive system; head; mesoderm; and musculature system. Orthologous to human PTCH2 (patched 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

207 figures from 147 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu467 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 29 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptch2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
medulloblastoma	Alliance	Medulloblastoma, somatic	155255
		Basal cell carcinoma, somatic	605462

Associated With ptch2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
coloboma	ptch2^{tc294z/tc294z}	standard conditions	Gordon et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000731	Sterol-sensing domain
Family	IPR003392	Protein patched/dispatched
Family	IPR004766	Transmembrane receptor, patched

Domain Details Per Protein

Protein	Length	Protein patched/dispatched	Sterol-sensing domain	Transmembrane receptor, patched
UniProtKB:Q98864 InterPro	1220
UniProtKB:F1Q8S0 InterPro	1442

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ptch2-201 (1) Ensembl	Ensembl		4,853 nt	Select Tool ZFIN BLAST
mRNA	ptch2-202 (1) Ensembl	Ensembl		4,420 nt	Select Tool

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ptch2		ptch2		Goat	IHC	Everest Biotech	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations