Gene
ptch2
- ID
- ZDB-GENE-980526-44
- Name
- patched 2
- Symbol
- ptch2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Acts upstream of or within several processes, including negative regulation of smoothened signaling pathway; osteoblast differentiation; and retinal ganglion cell axon guidance. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; digestive system; head; mesoderm; and musculature system. Used to study coloboma. Human ortholog(s) of this gene implicated in basal cell carcinoma and medulloblastoma. Orthologous to human PTCH2 (patched 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 209 figures from 149 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu467 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| medulloblastoma | Alliance | Medulloblastoma, somatic | 155255 |
| Basal cell carcinoma, somatic | 605462 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| coloboma | ptch2tc294z/tc294z | standard conditions | Gordon et al., 2018 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sterol-sensing domain | Transmembrane receptor, patched |
|---|---|---|---|
|
UniProtKB:Q98864
|
1220 | ||
|
UniProtKB:F1Q8S0
|
1442 |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ptch2 | Goat |
|
Everest Biotech
|
2 |
Plasmids
No data available