FIGURE

Fig. 7

ID

ZDB-FIG-090113-15

Publication

Esterberg et al., 2009 - dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity

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Fig. 7

fgfr expression is lost from the otic placode and hindbrain of Dlx3b/4b morphants. erm and fgfr1-3 expression are lost from the otic placode and hindbrain of Dlx3b/4b morphants (B,E,H,K). Brackets in (B,K) depict reduction of erm (B) and fgfr3 (K) staining in the hindbrain. Arrows in (E,H) depict loss of fgfr1 staining (E) from the otic placode and loss of fgfr2 staining (H) from the hindbrain of Dlx3b/4b morphants. erm and fgfr1-3 expression can be restored to the otic placode and hindbrain when cv2 mRNA is ectopically expressed in Dlx3b/4b morphants (C,F,I,L). (A–P) 6 somite embryos; dorsal view with anterior to the top. MHB, midbrain–hindbrain boundary; r1, rhombomere 1; r2, rhombomere 2; r3, rhombomere 3; r4, rhombomere 4; r6, rhombomere 6; op, otic placode.

Expression Data

Genes:	etv5b fgfr1a fgfr2 fgfr3
Fish:	WT WT + MO5-dlx3b + MO5-dlx4b
Knockdown Reagents:	MO5-dlx3b MO5-dlx4b
Anatomical Terms:	hindbrain neural rod midbrain hindbrain boundary neural rod otic placode presumptive rhombomere 3 presumptive rhombomere 4 presumptive rhombomere 6
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 325(1), Esterberg, R., and Fritz, A., dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity, 189-199, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.